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            Your Good Partner in Biology Research

            Wnt signaling pathway

            Wnt信號通路是一個復雜的蛋白質作用網絡,其功能最常見于胚胎發育和癌癥,但也參與成年動物的正常生理過程。如下圖所示,現在已發現三種Wnt信號通路,分別是經典Wnt通路(canonical Wnt pathway)、非經典Wnt/平面細胞極化通路(noncanonical Wnt/planar cell polarity pathway,PCP)和非經典Wnt/鈣離子通路(noncanonical Wnt/calcium pathway)。所有這三種Wnt信號通路都由Wnt蛋白配體與其受體卷曲受體的結合來激活,將信號傳給胞內的散亂蛋白。經典Wnt信號通路參與基因表達的調控,非經典平面細胞極化通路調控細胞骨架控制細胞形狀,非經典Wnt/鈣離子通路調控細胞內鈣離子的濃度。Wnt信號通路常用于臨近的細胞之間的通信(旁分泌)或同個細胞自身的通信(自分泌)。Wnt信號通路在動物中高度保守,從果蠅到人類都非常類似。



            粗大挺进尤物邻居少妇7

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